By David Moore
This ebook is geared toward the large neighborhood of scientists whose examine may benefit from attention of gravitational and house biology as one other measurement of environmental interference on their paintings. it is very important tension the varied molecular, mobile and physiological mechanisms, in all sorts of lifestyles, that are prompted by way of, or ultimately depending on, gravity or radiation. The publication brings jointly effects from house flight and ground-based experiments within the quite a few lifestyles technology disciplines that are scattered within the literature and infrequently released in assets now not simply to be had to the overall clinical neighborhood. a number of the effects bought are it appears contradictory of predictions of classical hypotheses and hence deserve frequent realization. The presentation emphasizes, a finished and significant overview of obtainable info, aiming not just to enhance entry to the knowledge, yet to remark additionally on its credibility and position it in right context. This well timed assessment also will gain these engaged in layout, overview and execution of existence technological know-how experiments in space.
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Additional resources for Biological and Medical Research in Space: An Overview of Life Sciences Research in Microgravity
A decrease of cytoplasmic frequency and velocity in Physarum. The transition from 1 x g to 0 X g induced - as seen before - an increase of frequency that was maximum 18-26 min after onset of 0 x g. The mean period decreased from 88 sec to 60 sec, after backregulation it rose to 98 sec. This high value persisted for nearly 2 h with mean period values of 98-99 sec. Except for a more pronounced reaction to 0 x g, the data from the clinostat were qualitatively and quantitatively confirmed. When the opposing effects of microgravity and white light were measured simultaneously, a mutual suppression of both responses was observed.
Phosphorylation of a 200-kDa detergent-soluble protein was observed after 20 min exposure to 35 x g. These results suggest that IP 3 and c-AMP may act as second messengers in hypergravity signal transduction. Phosphorylation of ipMAPs in both detergent-soluble and -insoluble fractions suggests that cytoskeletal structures may be influenced by gravity (Kumei et al. 1991). I/' I / r:~ ,. ·,.. ,. @ -.... ~"":::- /--~ / NUCLEUS ' ..... " I CELLULAR RESPO SE I c- os C- myc Fig. 3. Mechanism of T lymphocyte activation by Con A.
Less interesting for experiments in micro gravity and possible bioprocessing applications (in terms of proliferation rate and antibody production) appear to be hybridoma cells. This is not surprising, since hybridoma cells are ultimately committed to divide and to secrete antibodies with no, or little, possibility of regulation by external agents (Beaure d' Augeres et al. 1986; Bechler et al. 1993). Conversely, the electrofusion of immune cells to produce antibodies gave promising results in microgravity (Schnettler et al.
Biological and Medical Research in Space: An Overview of Life Sciences Research in Microgravity by David Moore